![]() How is Retin-A used for beauty treatments? Retin-A improves the cosmetic appearance of the skin, but it also helps treat some functional problems of the skin such as acne and precancerous conditions, such as actinic keratoses. Finally, the collagen bundles in the dermis will thicken and organize, causing the appearance of fine lines and wrinkles to lessen with time. The next effect seen is that the epidermal cells start to replicate faster causing the skin to look and feel softer, more robust and healthier. The earliest effect of Retin-A is that the outer layer of keratinocytes start shedding off, leaving the skin fresher, smoother and more evenly pigmented. In many ways, Retin-A can be thought of as reversing the outwards signs of aging on the skin. It works at the cellular level and takes several months to see the full effect. Retin-A is a topical medicine available by prescription only that is applied sparingly to the facial skin, sparing the eyelids and the corners of the nose and lips. The deeper layer of cells, called the dermis, and the collagen bundles become thinner and disordered, allowing for creases and fine wrinkles to more easily show the muscular activity from below. The pigmentation can become irregular and mottled because of this. The epidermal cells at the base also do not replicate as quickly, so the lifespan of these cells in the outer layer is much longer – and it shows. This leaves the skin looking dryer and rougher. ![]() ![]() The most superficial cells – the keratinocytes of the epidermis – tend to become more adhesive and hang around longer. To understand how Retin-A works, it helps to understand the effects of aging on the skin. One of the most successful patents of all time, it revolutionized topical skin care and still has great utility today. Retin-A, or tretinoin, is a form of vitamin A that was developed at the University of Pennsylvania in the 1960s. ![]()
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